Article
Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage.
The American journal of pathology - 1 Mar 1993
Hanby A M, Poulsom R, Singh S, Jankowski J, Hopwood D, Elia G, Rogers L, Patel K, Wright N A
Abstract excerpt
Hyperplastic polyps are common benign lesions of uncertain histogenesis, which occur in the colon in populations at risk for colorectal carcinoma. They contain neutral/MUC1 gene-related mucin which in turn is closely associated with the trefoil-peptide pS2, a major component of the ulcer-associated cell lineage, previously termed pseudopyloric metaplasia. We have examined 17 hyperplastic polyps for expression of...
Topics
- Cell Line
- Colonic Polyps
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Hyperplasia
- Immunohistochemistry
- In Situ Hybridization
- Intercellular Signaling Peptides and Proteins
- Membrane Glycoproteins