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Article

Clinical and prognostic evaluation of familial hypertrophic cardiomyopathy in two South African families with different cardiac beta myosin heavy chain gene mutations.

British heart journal - 1 Jul 1995

Posen B M, Moolman J C, Corfield V A, Brink P A

Abstract excerpt

BACKGROUND: Familial hypertrophic cardiomyopathy is the most common inherited cardiac disorder, with sudden cardiac death at a young age the most frequent cause of death in affected individuals. Some cases of familial hypertrophic cardiomyopathy are caused by missense mutations of the beta myosin heavy chain (beta MHC) gene on chromosome 14 and at least 17 such mutations have been described. Recent reports...

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Identifiers

PMID: 7662452
DOI: 10.1136/hrt.74.1.40
PMCID: PMC483944

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical and prognostic evaluation of familial hypertrophic cardiomyopathy in two South African families with different cardiac beta myosin heavy chain gene mutations.PMID 7662452Read ↗

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Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Clinical features, spectrum of causal genetic mutations and outcome of hypertrophic cardiomyopathy in South Africans.Semantic proximity Read ↗

Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.Semantic proximity Read ↗

The molecular genetics of hypertrophic cardiomyopathy: prognostic implications.Semantic proximity Read ↗

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