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Article

Inversion of the IDS gene resulting from recombination with IDS-related sequences in a common cause of the Hunter syndrome

1 Jan 1995

Abstract excerpt

We have recently described the identification of a second IDS locus (IDS-2) located within 90 kb telomeric of the IDS gene (Bondeson et al. submitted). Here, we show that this region is involved in a recombination event with the IDS gene in about 13% of patients with the Hunter syndrome. Analysis of the resulting rearrangement at the molecular level showed that these patients have suffered a recombination event...

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Identifiers

PMID: 7633410
DOI: 10.1093/hmg/4.4.615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inversion of the IDS gene resulting from recombination with IDS-related sequences in a common cause of the Hunter syndromePMID 7633410Read ↗

Presence of an IDS-related locus (IDS2) in Xq28 complicates the mutational analysis of Hunter syndrome.Semantic proximity Read ↗

IDS gene-pseudogene exchange responsible for an intragenic deletion in a Hunter patient.Semantic proximity Read ↗

An Alu-mediated rearrangement as cause of exon skipping in Hunter disease.Semantic proximity Read ↗

Novel Mutation in the IDS Gene in Hunter Syndrome Associated with Severe Cardiac Lesions.Semantic proximity Read ↗

Novel type of genetic rearrangement in the iduronate-2-sulfatase (IDS) gene involving deletion, duplications, and inversions.Semantic proximity Read ↗

Homologous nonallelic recombinations between the iduronate-sulfatase gene and pseudogene cause various intragenic deletions and inversions in patients with mucopolysaccharidosis type II.Semantic proximity Read ↗

Molecular analysis of patients with Hunter syndrome: implication of a region prone to structural alterations within the IDS gene.Semantic proximity Read ↗

Molecular and phenotypic variation in patients with severe Hunter syndrome.Semantic proximity Read ↗

Characterization of iduronate-2-sulfatase gene-pseudogene recombinations in eight patients with Mucopolysaccharidosis type II revealed by a rapid PCR-based methodSemantic proximity Read ↗

Recombination between two 14-bp homologous sequences as the mechanism for gene deletion in factor IX Seattle 1.Semantic proximity Read ↗

Mutations in the iduronate-2-sulfatase gene in five Norwegians with Hunter syndrome.Semantic proximity Read ↗

Insights into Hunter syndrome from the structure of iduronate-2-sulfatase.Semantic proximity Read ↗

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