Increased Cell Death and Reduced Neural Crest Cell Numbers in Ethanol‐Exposed Embryos: Partial Basis for the Fetal Alcohol Syndrome Phenotype

Abstract excerpt

Fetal alcohol syndrome (FAS) is characterized by growth retardation, craniofacial malformations, and heart and neural defects; the cellular and molecular mechanism(s) responsible for ethanol's teratogenicity remains unknown. Although the phenotype suggests that prenatal ethanol exposure perturbs neural crest cell development, direct proof that these cells are an in utero target is still lacking. Previous research...

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