Analysis of cybrids harboring MELAS mutations in the mitochondrial tRNA(Leu(UUR)) gene.

doi:10.1002/mus.880181424

Back to search

Article

Analysis of cybrids harboring MELAS mutations in the mitochondrial tRNA(Leu(UUR)) gene.

Muscle & nerve. Supplement - 1 Jan 1995

Koga Y, Davidson M, Schon E A, King M P

Abstract excerpt

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes), a maternally inherited mitochondrial disorder, has been associated with an A-->G transition at nucleotide 3243 and a T-->C transition at nucleotide 3271, both in the mitochondrial tRNA(Leu(UUR)) gene. We tra...

Topics

Genes
Humans
MELAS Syndrome
Mitochondria
Mutation
Oxygen Consumption
RNA, Ribosomal
RNA, Transfer, Leu

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.