Article
KAL, a gene mutated in Kallmann's syndrome, is expressed in the first trimester of human development.
Molecular and cellular endocrinology - 28 Apr 1995
Duke V M, Winyard P J, Thorogood P, Soothill P, Bouloux P M, Woolf A S
Abstract excerpt
Kallmann's syndrome (KS) is characterised by the association of anosmia and isolated hypogonadotrophic hypogonadism (IHH). Mutations of the KAL gene which is located at Xp22.3 cause X-linked KS (XKS). In this study we used the reverse transcriptase polymerase chain reaction and in situ hybridisat...
Topics
- Base Sequence
- Female
- Fetus
- Gene Expression
- Gestational Age
- Humans
- In Situ Hybridization
- Kallmann Syndrome
- Kidney
- Mesonephros
- Molecular Sequence Data
- Mutation
- Olfactory Bulb
- Polymerase Chain Reaction
- Pregnancy
- RNA, Messenger
- RNA-Directed DNA Polymerase
- Spinal Cord