Article
Differences in the regulation of specific glycosylation in the pathogenesis of paroxysmal nocturnal hemoglobinuria and the Tn-syndrome.
Experimental hematology - 1 Mar 1994
Thurnher M, Fehr J, Berger E G
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder that resembles in several aspects the Tn-syndrome, in which bone marrow-derived cells are deficient in mucin-type beta 1,3 galactosyltransferase (beta 1,3Gal-T) due to the persistent repression of an intact allele. In t...
Topics
- Adult
- Alleles
- Antigens, CD
- Azacitidine
- Bone Marrow
- Butyrates
- Butyric Acid
- CD48 Antigen
- CD8 Antigens
- Cells, Cultured
- Flow Cytometry
- Galactosyltransferases
- Gene Expression Regulation, Enzymologic
- Glycosylation
- Hematologic Diseases
- Hemoglobinuria, Paroxysmal
- Humans
- Leukosialin