Beta-S gene cluster haplotypes modulate hematologic and hemorheologic expression in sickle cell anemia. Use in predicting clinical severity.

Article

Beta-S gene cluster haplotypes modulate hematologic and hemorheologic expression in sickle cell anemia. Use in predicting clinical severity.

The American journal of pediatric hematology/oncology - 1 Feb 1994

Powars D R, Meiselman H J, Fisher T C, Hiti A, Johnson C

Abstract excerpt

PURPOSE: The rate of progression of major organ failure in sickle cell anemia is genetically controlled. It is the direct consequence of the sickle cell-evoked vasculopathy. PATIENTS AND METHODS: Presence of the beta S gene cluster haplotypes and alpha gene deletions as genetic markers indicate t...

Topics

Anemia, Sickle Cell
Fetal Hemoglobin
Globins
Haplotypes
Humans
Multigene Family
Phenotype
Rheology

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