Article
[Vörner keratosis palmoplantaris diffusa. Clinical, formal genetic and molecular biology studies of 22 families].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - 1 Oct 1995
Küster W, Zehender D, Mensing H, Hennies H C, Reis A
Abstract excerpt
In 1901, Vörner described a diffuse keratoderma of palms and soles with autosomal dominant inheritance. Histopathologically, this disease has the typical features of epidermolytic hyperkeratosis. Clinical examination does not allow differentiation between keratoderma of the Vörner type and the keratoderma described by Thost in 1880 and Unna in 1883. Reexamination of the family originally seen by Thost revealed...
Topics
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 18
- Female
- Genes, Dominant
- Humans
- Keratins
- Keratoderma, Palmoplantar, Diffuse
- Male
- Phenotype
- Point Mutation