Outbreaks of fluconazole-resistant Candida parapsilosis are driven by low-biofilm-producing isolates that emerge under host selection.

doi:10.1371/journal.pbio.3003973

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Article

Outbreaks of fluconazole-resistant Candida parapsilosis are driven by low-biofilm-producing isolates that emerge under host selection.

PLoS biology - 1 Sept 2026

Daneshnia Farnaz, Gunasekaran Deepika, Bergin Sean, Lombardi Lisa, Perry Austin M, Cai Liuyang, Walker Louise A, Nemeth Tibor, Hilmioglu-Polat Süleyha, Salzberg Letal I, Ebadati Arefeh, Köhler Tobias, Braune Gabriel, de Almeida João N, Caggiano Giuseppina, Kus Julianne V, Mosharaf Ghahfarokhy Pegah, Munoz Julieta, Floyd Daniel J, Fuentes-Palacios Diego, Gonçalves Samuel M, Gonçales Relber A, Salehi Mostafa, Desai Jigar V, Carvalho Agostinho, Mei Shenglin, Munro Carol A, Hopke Alex, Gabaldón Toni, Gacser Attila, Kurzai Oliver, Butler Geraldine, Perlin David S, Fang Wenjie, Nobile Clarissa J, Mansour Michael K, Arastehfar Amir

Abstract excerpt

Candida parapsilosis is a major human fungal pathogen, with recent global outbreaks driven by fluconazole-resistant (FLCR-Cp) isolates that are difficult to eradicate and associated with poor clinical outcomes. However, the microbial traits enabling persistence of these outbreak lineages remain poorly defined. Here, we show that FLCR-Cp isolates responsible for prolonged, multi-country outbreaks consistently...

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Topics

Biofilms
Candida parapsilosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fluconazole

Drug Resistance, Fungal

Humans

Antifungal Agents

Disease Outbreaks

Candidiasis

Whole Genome Sequencing

Phenotype

Animals

Source

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Identifiers

PMID: 42679010
DOI: 10.1371/journal.pbio.3003973
PMCID: PMC13557500

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