Article
Clinical Resistance to Lenacapavir During Treatment of HIV Infection: A Review.
Viruses - 8 Aug 2026
Margot Nicolas A, Callebaut Christian
Abstract excerpt
Lenacapavir (LEN) is the first-in-class capsid inhibitor that inhibits HIV capsid function in vitro with picomolar activity. LEN has been approved for the treatment of HIV in combination with other antiretroviral agents (ARVs), as well as for the prevention of acquisition of HIV-1 in people who may benefit from pre-exposure prophylaxis (PrEP). In vitro investigations of the resistance profile of LEN have...
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