Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats.

doi:10.3390/ijms27167376

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Article

Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats.

International journal of molecular sciences - 18 Aug 2026

Weigele Jochen, Franco Antonietta, Dorn Gerald W

Abstract excerpt

Charcot-Marie-Tooth (CMT) disease type 2A is a rare heritable disorder caused by pathogenic variants of mitofusin (MFN) 2 that suppress mitochondrial fusion and motility in peripheral nerves, culminating in denervation myoatrophy. The rarity of this condition and the limited choice of animal models preclude pre-clinical evaluation of many tests that could be translated to human trials. Here, we introduced the...

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PMID: 42653381
DOI: 10.3390/ijms27167376
PMCID: PMC13513834

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MFN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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