Beta-Globin (HBB) Mutations and Catalase Gene Polymorphisms in Beta-Thalassemia Major Patients in Al-Diwaniyah, Iraq.

doi:10.3390/genes17080906

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Beta-Globin (HBB) Mutations and Catalase Gene Polymorphisms in Beta-Thalassemia Major Patients in Al-Diwaniyah, Iraq.

Genes - 31 Jul 2026

Fairooz Huda Ahmed, Abdelhedi Rania, Khalil Sarab Hussain, Kharrat Najla, Hmani Mounira

Abstract excerpt

Background/Objectives: β-thalassemia major is a common inherited hemoglobin disorder caused by Hemoglobin Subunit Beta (HBB) mutations and often complicated by iron overload and oxidative stress. This study characterized the clinical, hematological, biochemical, and molecular profile of β-thalassemia major in Al-Diwaniyah, Iraq, focusing on HBB mutations and CAT promoter polymorphisms as oxidative modifiers....

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PMID: 42650099
DOI: 10.3390/genes17080906
PMCID: PMC13511826

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