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Article

The Prognostic Significance of EGFR Adjusted Variant Allele Frequency on First-Line Osimertinib Efficacy in Advanced EGFR-Mutant NSCLC.

Current oncology (Toronto, Ont.) - 23 Jul 2026

Phillips William J, Leong Russell, Yeung Benjamin, Al Lawati Ahmed, Camidge D Ross, Lo Bryan, Wheatley-Price Paul

Abstract excerpt

Introduction: The prognostic significance of EGFR variant allele frequency (VAF) remains unclear in advanced EGFR-mutant (EGFR-mt) NSCLC. We examined the relationship of EGFR VAF and clinical outcomes in patients treated with first-line osimertinib. Methods: This retrospective cohort study evaluated patients with advanced EGFR-mt NSCLC treated at the Ottawa Hospital between July 2021 and June 2023. Baseline...

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Identifiers

PMID: 42645345
DOI: 10.3390/curroncol33080439
PMCID: PMC13511178

Genes

EGFR

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