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Article

First Identification of HEV Subtype 3i in Human Hepatitis E Cases in Central Italy.

Viruses - 27 Jun 2026

Bruni Roberto, Equestre Michele, Curini Valentina, Camilloni Barbara, Bozza Silvia, Graziani Alessandro, Picchi Giovanna, Marcantonio Cinzia, Arcopinto Ludovica, Costanzi Giulia, Mataj Elida, Suffredini Elisabetta, Vicenza Teresa, Borghi Monica, Farneti Silvana, Staltari Orietta, Rughetti Anna, Madonna Elisabetta, Aprea Giuseppe, Cammà Cesare, Garbuglia Anna Rosa, Ciccaglione Anna Rita

Abstract excerpt

HEV genotype 3 is classified into several subtypes. In Italy, 3f, 3c, 3e and, rarely, 3a subtypes are usually detected in human hepatitis E cases: the present study documents, for the first time, the detection of the 3i subtype, previously described in Italy exclusively from wild boars. Routine surveillance by short Sanger sequences highlighted five hepatitis E cases with unusual HEV subtype between 2019 and 2023...

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Identifiers

PMID: 42515561
DOI: 10.3390/v18070709
PMCID: PMC13431625

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