Article
Allele-specific methylation of MRP3 drives mating type determination in a marine diatom.
Science advances - 24 Jul 2026
Ruggiero Antonella, Manfellotto Francesco, Mager Svenja, di Costanzo Federica, Gerber Tobias, Broccoli Andrea, Di Tuccio Viviana, Nishimura Tomohiro, Sollitto Marco, Pan Leslie, Pallavicini Alberto, Russo Monia T, Sanges Remo, Ferrante Maria I
Abstract excerpt
Sex determination mechanisms exhibit remarkable diversity across eukaryotic lineages. In the pennate diatom Pseudo-nitzschia multistriata, sex is determined by MRP3, a gene with unknown function, which is monoallelically expressed in sexually competent mating type plus (MT+) cells and silenced in MT- cells. Here, we describe an allelic-specific methylation pattern at the sex locus, with a hypomethylated allele...
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