Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type I interferonopathies: 15 years after the concept-news and views.

Current opinion in rheumatology - 1 Sept 2026

Khaldi-Plassart Samira, Melki Isabelle, Frémond Marie-Louise

Abstract excerpt

PURPOSE OF REVIEW: Genetic autoinflammatory conditions constitute an increasing field. Among them, type I interferonopathies (IFNp-I) were conceptualized 15 years ago as inborn errors of immunity due to chronic activation of the type I interferon (IFN-I) signalling pathway. Here, we provide recent insights in genetic mechanisms, clinical phenotypes and therapeutic options for these severe and rare disorders....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases of the Nervous System
Share to Hereditary Autoinflammatory Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon Type I

Share to Nervous System Malformations

Share to Phenotype

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Receptor, Interferon alpha-beta

Share to Signal Transduction

Source

Identifiers

PMID: 42470122
DOI: 10.1097/BOR.0000000000001179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type I interferonopathies: 15 years after the concept-news and views.PMID 42470122Read ↗

<i>PTPN1</i> -related autoinflammation is a common cause of Aicardi-Goutières Syndrome with reduced penetranceSemantic proximity Read ↗

Type I Interferonopathies: from a Novel Concept to Targeted Therapeutics.Semantic proximity Read ↗

Type I Interferonopathies in Childhood.Semantic proximity Read ↗

Monogenic interferon-mediated diseases: novel phenotype and genotype characteristics from a Saudi population.Semantic proximity Read ↗

Interferonopathies masquerading as non-Mendelian autoimmune diseases: pattern recognition for early diagnosisSemantic proximity Read ↗

[When to consider type I interferonopathy in adulthood?]Semantic proximity Read ↗

Interferonopathies: From concept to clinical practiceSemantic proximity Read ↗

Pathogenic insights from genetic causes of autoinflammatory inflammasomopathies and interferonopathiesSemantic proximity Read ↗

[Type I interferonopathies. Literature review].Semantic proximity Read ↗

Type I interferonopathies—an expanding disease spectrum of immunodysregulationSemantic proximity Read ↗

Autoinflammatory diseases: update on classification diagnosis and managementSemantic proximity Read ↗

Inflammatory turmoil within: an exploration of autoinflammatory disease genetic underpinnings, clinical presentations, and therapeutic approachesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.