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Independent and joint effect of genetic susceptibility and long-term PM2.5 exposure on coronary artery disease risk: A large-scale cohort study.

Ecotoxicology and environmental safety - 1 Sept 2026

Lin Yu-Ting, Lin Yi-Ting, Jung Chau-Ren, Chen Hung-Lin, Chiang Hsiu-Yin, Chen Yi-Yun, Chiang Min-Yu, Wu Ping-Hsun, Tsai Tsung-Lin, Hwang Bing-Fang, Kuo Chin-Chi

Abstract excerpt

BACKGROUND: Long-term exposure to fine particulate matter ≤ 2.5 μm (PM2.5) is a major cardiovascular risk factor, yet its interaction with genetic susceptibility in coronary artery disease (CAD) remains uncertain. We investigated the independent and joint effects of PM2.5 and polygenic risk on incident CAD. METHODS: A genome-wide polygenic risk score (PRS) was derived using a five-fold cross-validation framework...

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Air Pollutants
Coronary Artery Disease
Environmental Exposure
Gene-Environment Interaction

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Genetic Risk Score

Particulate Matter

Proportional Hazards Models

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PMID: 42431065
DOI: 10.1016/j.ecoenv.2026.120487

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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