Article
A large-scale multi-ancestry mitochondrial variant association analysis for cardiometabolic traits.
Nature communications - 4 Jul 2026
Zhou Jin J, Jensen Aubrey, Samuels David C, Markianos Kyriacos, Zhou Hua, Zhang Hinn, Vujkovic Marijana, Lynch Julie A, Dinatale Tia, Joseph Jacob, Liu Chunyu, Hung Adriana, Sun Yan V, Pyarajan Saiju, Tsao Philip S, Chang Kyong-Mi, Hulgan Todd, Reaven Peter
Abstract excerpt
Studies linking mitochondrial DNA (mtDNA) with complex traits are often limited by small sample sizes or focused on specific phenotypes in clinically selected cohorts. Here, we use data from >600,000 participants in the Million Veteran Program (MVP) to perform a multi-ancestry analysis of mitochondrial DNA (mtDNA) variation and cardiometabolic phenotypes across European (EUR), African (AFR), Admixed American...
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