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Article

Clustering-based stratification of fibromyalgia subtypes: A comparative analysis of medicated and non-medicated cohorts from two academic centers.

Seminars in arthritis and rheumatism - 1 Oct 2026

Hackshaw Kevin V, Osuna-Diaz Michelle M, Sebastian Katherine R, Nuguri Shreya Madhav, Castellvi Silvia de Lamo, Mele Emily C, Yu Lianbo, Giusti M Monica, Mikulik Zhanna, Rodriguez-Saona Luis

Abstract excerpt

Fibromyalgia (FM) exhibits substantial clinical heterogeneity, yet reproducible symptom phenotypes with relevance for treatment personalization remain poorly defined. This study examined whether distinct FM phenotypes emerge consistently across medicated and unmedicated individuals. We analyzed 558 adults meeting the 2016 ACR criteria recruited from two academic centers. Participants completed standardized...

Read the complete abstract on PubMed

Topics

Humans
Fibromyalgia
Female
Cluster Analysis
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Clustering Algorithms

Phenotype

Male

Severity of Illness Index

Pain Measurement

Source

Identifiers

PMID: 42385563
DOI: 10.1016/j.semarthrit.2026.153036

Genes

ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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