Article
Understanding risk perception and risk-reducing decision-making for surgery among individuals with a genetic predisposition to epithelial ovarian cancer.
Journal of genetic counseling - 1 Aug 2026
Kukurudz-Gorowski Rebekah, Horn Sylvia, Lambert Pascal, Serfas Kim, El-Gabalawy Renée, Altman Alon David, McManus Kirk James, Hartley Jessica Nicole, Nachtigal Mark William
Abstract excerpt
Genetic predisposition to hereditary breast and ovarian cancer and Lynch syndrome increases the risk of developing cancer, including epithelial ovarian cancer (EOC). Depending on the pathogenic variant, (e.g., BRCA1 or PMS2) the risk of developing EOC ranges from approximately 3%-60%. To reduce this risk, many individuals are offered risk-reducing salpingo-oophorectomy (RRSO), a procedure in which fallopian tubes...
Topics
- Humans
- Female
- Genetic Predisposition to Disease
- Ovarian Neoplasms
- Carcinoma, Ovarian Epithelial
- Decision Making
- Middle Aged
- Adult
- Salpingo-oophorectomy
- Risk Reduction Behavior
- Aged
- Risk Assessment