Article
PCIS1 is an essential factor in mitochondrial RNA splicing and complex I biogenesis, with distinct effects in null and downregulated mutants.
Plant cell reports - 29 Jun 2026
Kobaivanov Ella, Frink Brody, Takenaka Mizuki, Ostersetzer-Biran Oren
Abstract excerpt
KEY MESSAGE: PCIS1 is indispensable for plant mitochondria NAD4 and NAD7 gene expression. Null mutants abolish CI assembly and arrest embryogenesis, whereas knockouts retain partial splicing, revealing a genetic functional mt-RNA metabolism threshold. Plant mitochondrial biogenesis relies on the splicing of numerous group II introns, primarily in genes encoding complex I (CI) subunits, which require multiple...
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