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Article

Dual E-Cigarette Users Show Nicotine Addiction Risk Alleles and Nuclear Abnormalities in Oral Epithelial Cells.

Advances in respiratory medicine - 18 Jun 2026

Montero-Ruiz Oreth, Falfán-Valencia Ramcés, Buendía-Roldán Ivette, Valencia-Pérez Rea Daniela, Rueda-Munive Gibran E, Fricke-Galindo Ingrid, García-Carmona Salvador, Abarca-Rojano Edgar, Pérez-Rubio Gloria

Abstract excerpt

BACKGROUND: This study was conducted to identify genetic risk variants associated with nicotine addiction in the CHRNA5, HTR2A, DRD4, and CYP2A6 genes among electronic cigarette users who also smoke combustible cigarettes (dual users), and to assess potential genotoxic and cytotoxic damage in the oral mucosal cells of the study population. METHODS: We included dual e-cig users (ECIG, n = 70), combustible...

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Source

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Identifiers

PMID: 42345644
DOI: 10.3390/arm94030039
PMCID: PMC13295726

Genes

CHRNA5
CYP2A6
DRD4
HTR2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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