Association of IL-10 promoter and IL-12 gene polymorphisms with the risk of symptomatic Helicobacter pylori infection.

doi:10.1186/s12876-026-05054-3

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Article

Association of IL-10 promoter and IL-12 gene polymorphisms with the risk of symptomatic Helicobacter pylori infection.

BMC gastroenterology - 25 Jun 2026

Karami Pezhman, Mokari Sama, Alikhani Mohammad Yousef, Kazemi Sima, Mirzaei Mina, Soltanian Alireza, Ahmadyousefi Mohammad, Dehdar Fereshteh, Haghi Alireza Rastgoo, Azizi Ebrahim

Abstract excerpt

BACKGROUND: The host's immune response to Helicobacter pylori (H. pylori) infection is largely determined by its cytokine profile. Genetic variations within crucial immunomodulatory genes, including those for interleukin-10 (IL-10) and interleukin-12 (IL-12), are thought to influence an individual's vulnerability to the infection and its clinical consequences by modifying cytokine production. Nonetheless,...

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Topics

Humans
Helicobacter Infections
Interleukin-10
Female
Case-Control Studies
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Interleukin-12

Helicobacter pylori

Genetic Predisposition to Disease

Iran

Promoter Regions, Genetic

Adult

Middle Aged

Genotype

Polymorphism, Single Nucleotide

Polymorphism, Genetic

Source

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Identifiers

PMID: 42343242
DOI: 10.1186/s12876-026-05054-3
PMCID: PMC13556027

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