Emergence of two novel HIV-1 Circulating Recombinant Forms (CRF190_0708 and CRF191_0708): molecular characterization and clinical insights from a five-year study in Yunnan, China.

doi:10.1186/s12866-026-05323-x

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Emergence of two novel HIV-1 Circulating Recombinant Forms (CRF190_0708 and CRF191_0708): molecular characterization and clinical insights from a five-year study in Yunnan, China.

BMC microbiology - 23 Jun 2026

Gao Li, Chang Wei, Shu Yuanlu, Liu Yang, Zhang Mi, Yang Qian, Li Jianjian, Pai HongYe, Huang Lingling, Chen Yongjiao, Yang Zhiqing, Lu Fei, Dong Xingqi, Feng Yue, Xia Xueshan

Abstract excerpt

BACKGROUND: To characterize HIV-1 molecular epidemiology and identify novel circulating recombinant forms (CRFs) among antiretroviral therapy (ART)-naïve heterosexuals in Yunnan, China, and evaluate their clinical impact. METHODS: This study examined 636 HIV-1 pol sequences to analyze genetic diversity, pretreatment drug resistance (PDR), and transmission networks. Near full-length genomes were obtained to...

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Topics

Adult
Female
Humans
Male
Middle Aged
China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Viral

Evolution, Molecular

Genetic Variation

Genome, Viral

Genotype

HIV Infections

HIV-1

Molecular Epidemiology

Phylogeny

Recombination, Genetic

Source

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Identifiers

PMID: 42332571
DOI: 10.1186/s12866-026-05323-x
PMCID: PMC13540875

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