Article
Genomic conservation and CNS-associated intra-host variation of Nipah virus during the 1998-1999 Malaysian outbreak.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2026
Cheong Heng Choon, Tan Foo Hou, Ong Hui Ming, Wong Kum Thong, Ong Kien Chai, Tan Soon Hao, Tan Chong Tin, Wong Li Ping, Schee Jie Ping, Mohd-Zain Rozainanee, Rahim Aziyah Mat, Idris Nuryana, Tee Kok Keng, Chang Li-Yen
Abstract excerpt
OBJECTIVES: Nipah virus (NiV) is a highly pathogenic henipavirus responsible for recurrent outbreaks of severe encephalitis. This study aimed to address gaps in historical genomic data by characterizing NiV genomes recovered from archived central nervous system (CNS) tissues from the 1998 to 1999 Malaysian outbreak and evaluating viral evolution and intra-host genetic variation. METHODS: We analyzed 18 NiV...
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