Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study.

doi:10.1186/s12902-026-02336-5

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Article

Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study.

BMC endocrine disorders - 18 Jun 2026

Shi Xueqin, Wang Qianqian, Yin Wenli, Zhou Chong

Abstract excerpt

BACKGROUND: Childhood obesity is frequently accompanied by endocrine dysfunction and genetic susceptibility, but their combined contribution to metabolic risk remains insufficiently defined. This retrospective study evaluated hormonal, metabolic, and genetic determinants of metabolic syndrome (MetS) in children and adolescents with obesity. METHODS: Electronic medical records from January 2021 to May 2025 were...

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Topics

Humans
Female
Retrospective Studies
Metabolic Syndrome
Child
Male
Pediatric Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Adolescent

Polymorphism, Single Nucleotide

Insulin Resistance

Receptor, Melanocortin, Type 4

Receptors, Leptin

Genetic Predisposition to Disease

Follow-Up Studies

Risk Factors

Prognosis

Biomarkers

Source

Open in PubMed Open full text

Identifiers

PMID: 42316387
DOI: 10.1186/s12902-026-02336-5
PMCID: PMC13543467

Genes

FTO
MC4R
LEPR

Provenance

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