The causative mutation for muffs and beard phenotype correlates with gene expression profile in chicken embryonic brains: an RNA-seq analysis.

doi:10.1016/j.psj.2026.107232

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Article

The causative mutation for muffs and beard phenotype correlates with gene expression profile in chicken embryonic brains: an RNA-seq analysis.

Poultry science - 1 Sept 2026

Zheng Xiaotong, Liu Li, Niu Ziqiu, Li Yimeng, Liu Zhengyang, Shu Xin, Wang Hui, Xu Bingjie, Wang Yutong, Chen Jianfei, Zhang Hao

Abstract excerpt

A complex structural variation on chicken chromosome 27 is the causal mutation for the muffs and beard (Mb) phenotype. The Mb variant region contains copy number variations in several genes important for nervous system development, including HOXB8, HOXB7, and SMARCE1. However, it was previously unknown whether genes in this region are expressed in the brain or influence neural development. In this study, we...

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