Critical Biological Functions and Clinical Implications of Epigenetic-Related Candidate Biomarkers in Chronic Obstructive Pulmonary Disease: Integrated Machine Learning Screening and Basic Experimental Validation.

Abstract excerpt

Background: Chronic obstructive pulmonary disease (COPD) is the primary cause of deaths related to respiratory diseases. Epigenetic modifications are crucial in the development of mammals, and any disruption to epigenetic regulation may result in disease. Methods: We performed differential expression analysis on the GSE19407, GSE11784 and GSE20257 datasets from the Gene Expression Omnibus (GEO) dataset and...

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