Article
Stress-strain phenotyping, reverse remodelling and therapeutic responsiveness in HFrEF: Predictive value of end-systolic wall stress and global longitudinal strain.
International journal of cardiology - 1 Oct 2026
Dini Frank L, Carluccio Erberto, Bakalli Aurora, Acquaro Mauro, Barletta Valentina, Galeotti Giangiacomo, Bajraktari Gani, Ghio Stefano, Henein Michael Y
Abstract excerpt
BACKGROUND: Left ventricular (LV) reverse remodelling (LVRR) is a key therapeutic objective in heart failure (HF) with reduced ejection fraction (HFrEF), yet only a subset of patients exhibit meaningful recovery despite guideline-directed medical therapy (GDMT). End-systolic wall stress (ESWS) and global longitudinal strain (GLS) reflect complementary aspects of myocardial mechanics. This study evaluated whether...
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