Clonal and plasmid-mediated dissemination of mcr-1 in Escherichia coli strains at the human-companion animal interface: Genomic characterisation of colistin resistance plasmids.

Abstract excerpt

The global emergence of plasmid-mediated colistin resistance (mcr-1) gene poses a critical threat to human and animal health due to its ability for horizontal dissemination. While the role of food-producing animals is well recognised, the contribution of companion animals and household environments to the persistence and circulation of mcr-1 remains poorly understood. In this study, we investigated the genetic...

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