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Article

Molecular Pathology of Soft-tissue Neoplasms.

Surgical pathology clinics - 1 Jun 2026

Pan Boju, Ren Dong, Rasool Ghulam, Brohl Andrew S, Bui Marilyn M

Abstract excerpt

Soft-tissue tumors are rare mesenchymal neoplasms characterized by extensive morphologic and genetic heterogeneity. Advances in molecular pathology have transformed their diagnosis, classification, and therapeutic management. Recurrent genomic alterations such as gene fusions, mutations, amplifications, and epigenetic changes define distinct tumor subtypes, guiding targeted therapy. Modern diagnostic platforms,...

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PMID: 42091273
DOI: 10.1016/j.path.2026.02.001

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