Article
Lynch syndrome integrative epidemiology and genetics (LINEAGE): rationale for cohort design.
Familial cancer - 6 May 2026
Patel Swati G, Loomans-Kropp Holli A, Foda Zachariah H, Katona Bryson W, Birz Suzi, Burke Carol A, Clawson Jordan, Furner Brian, Hochheimer Camille, Magnan Elizabeth, Ricciardiello Luigi, Singh Harminder, Volchenboum Samuel, Watkins Michael, Yen Timothy, Abbass Mohammad, Bartell Nicholas J, Dudley Beth, Engelking Luke, Guillem Jose, Hollis Robert, Idos Gregory, Jones Blake A, Kanth Priyanka, Kastrinos Fay, Li Dan, Lucas Aimee L, Mankaney Gautam N, Maratt Jennifer K, Marino Danielle, Melson Joshua, Nguyen Long H, Reddy Kavya M, Schrader Kasmintan A, Silva-Smith Rachel, Singh Aparajita, Stanich Peter P, Stoffel Elena M, Syngal Sapna, Weiss Jennifer M, Yurgelun Matthew B, Zakalik Dana, Gupta Samir, Bansal Ajay, Kupfer Sonia S
Abstract excerpt
BACKGROUND: The Lynch syndrome INtegrative Epidemiology And GEnetics (LINEAGE) consortium was established to address gaps in understanding genotype-specific cancer risks and risk-modifiers in contemporary North American Lynch syndrome (LS) populations. LINEAGE is a multi-center, longitudinal cohort to systematically collect data on risk factors, adherence to care, quality of surveillance, and patient-, provider-,...
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