Article
Lymphatic Abnormalities in Noonan Syndrome Extend Beyond Clinically Apparent Disease.
American journal of medical genetics. Part A - 1 Oct 2026
Sheyanth Inger Norlyk, Kelly Benjamin, Mohanakumar Sheyanth, Ringgaard Steffen, Dori Yoav, Nielsen Irene Kibæk, Jensen Uffe Birk, Hjortdal Vibeke Elisabeth
Abstract excerpt
Lymphatic disease represents a well-described manifestation of Noonan syndrome (NS), yet the full phenotypic spectrum remains incompletely characterized, especially in asymptomatic individuals. We conducted a cross-sectional study including 10 individuals with NS (four with peripheral lymphedema and six without) and 10 age- and sex-matched cardiovascularly healthy controls. Central lymphatic anatomy was...
Read the complete abstract on PubMedTopics
- Humans
- Noonan Syndrome
- Female
- Male
- Child
- Cross-Sectional Studies