Unsupervised radiomics-driven endotyping of chronic rhinosinusitis with nasal polyps: a multimodal characterization of CT imaging, clinical phenotypes, and proteomic profiling.

Abstract excerpt

BACKGROUND: The current phenotyping of chronic rhinosinusitis with nasal polyps (CRSwNP) into eosinophilic (eCRSwNP) and non-eosinophilic (non-eCRSwNP) subtypes is increasingly insufficient to address complex clinical challenges, especially as some non-eCRSwNP patients have poor prognoses. Identifying intrinsic endotypes non-invasively is crucial for precision therapy. To identify CRSwNP endotypes via...

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