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Article

Prevalence of the AIM exon 3 duplication variant, a putative biomarker associated with progression of kidney disease, in 1000 cats.

Journal of feline medicine and surgery - 1 May 2026

Villarino Nicolas F, Hwang Julianne K, Mealey Katrina L

Abstract excerpt

ObjectivesA protein called apoptosis inhibitor of macrophages (AIM) helps clear waste from the kidney tubules. Some domestic cats harbor a duplication of exon 3 in the AIM gene, producing a four-domain AIM protein that includes an additional scavenger receptor cysteine-rich subunit. This variant has been associated with increased risk of chronic kidney disease. Pilot studies suggest that homozygosity for this...

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Identifiers

PMID: 41994863
DOI: 10.1177/1098612X261445138
PMCID: PMC13213088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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