Oxygen diffusion kinetics, buffering capacity and phenotype: A narrative review of oxygen physiology and later phenotype in very preterm infants.

Abstract excerpt

Clinicians often view exposure to supplementary oxygen in preterm infants as a simple reciprocal trade-off between mortality and the risk of vision-threatening retinopathy, but this perspective oversimplifies the underlying physiology. Oxygen moves through a series of spatially distinct compartments without intrinsic regulation, with Fick's law governing the entire process. We suggest that retinopathy of...

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