Association of maternal multiple serum metal/metalloid concentrations and metabolic gene polymorphisms with offspring skeletal defects: a multicenter case-control study.

Abstract excerpt

BACKGROUND: Skeletal defects (SDs) can be caused by various factors, including genetic and environmental factors, as well as gene-environment interactions. This study aimed to investigate the association of maternal serum concentrations of metals/metalloids and metabolic gene polymorphisms with offspring SDs risk, including their potential interactions. METHODS: In this multicenter case-control study, 316...

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