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Article

Optic Atrophy in Wolfram Syndrome Type 1: A Retrospective Analysis of Visual Outcomes and Biomarker Correlates.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 1 Sept 2026

McNeely Bradley J, Tang Abby F, Urano Fumihiko, Levergood Nicholas R, Ko Melissa W, Mackay Devin D, Van Stavern Gregory P, Tang Yunshuo

Abstract excerpt

BACKGROUND: Wolfram syndrome type 1 (WS1) is a rare autosomal recessive disorder classically associated with diabetes mellitus (DM) and optic atrophy (OA). We aimed to characterize OA in WS1 and evaluate optical coherence tomography (OCT) and genetic biomarkers as tools for disease monitoring and prognostication. METHODS: We conducted a retrospective chart review of genetically confirmed patients with WS1 seen at...

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Identifiers

PMID: 41870390
DOI: 10.1097/WNO.0000000000002451

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Optic Atrophy in Wolfram Syndrome Type 1: A Retrospective Analysis of Visual Outcomes and Biomarker Correlates.PMID 41870390Read ↗

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Wolfram Syndrome Type I Case Report and Review-Focus on Early Diagnosis and Genetic Variants.Semantic proximity Read ↗

Wolfram syndrome type 1: a case series.Semantic proximity Read ↗

The phenotypic spectrum of syndromic optic atrophy associated with variants in WFS1: with reclassification of p.Val606Gly as a likely benign variant.Semantic proximity Read ↗

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Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.Semantic proximity Read ↗

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