Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis.

doi:10.1681/ASN.0000001060

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Article

Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis.

Journal of the American Society of Nephrology : JASN - 1 Sept 2026

Usui Toshiaki, Ishibashi Shun, Tanaka Ryojiro, Morito Naoki, Hamada Michito, Gogoleva Natalia, Ning Baoshuo, Kumaga Eugenia, Oki Mayuko, Tsunakawa Yuki, Murakami Yuka, Sadaki Shunya, Fuseya Sayaka, Kanai Maho, Nishino Teppei, Inoue Yuri, Sato Yoshinori, Gochi Kei, Shinohara Masahiro, Kuno Akihiro, Jeon Hyojung, Warabi Eiji, Kudo Takashi, Mizuno Seiya, Muratani Masafumi, Levine Michael A, Yamagata Kunihiro, Takahashi Satoru

Abstract excerpt

KEY POINTS: Multicentric carpotarsal osteolysis, a rare disorder, causes progressive osteolysis and kidney failure because of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) gene mutations. A genome-edited mouse model carrying the multicentric carpotarsal osteolysis mutation was used to obtain a deeper understanding of this rare disease. Targeting MAFB/IGF-1/PI3K/AKT signaling may provide...

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Topics

Animals
MafB Transcription Factor
Proto-Oncogene Proteins c-akt

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Signal Transduction

Mice

Phosphatidylinositol 3-Kinases

Osteolysis

Glomerulosclerosis, Focal Segmental

Disease Models, Animal

Mutation

Male

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 41842942
DOI: 10.1681/ASN.0000001060
PMCID: PMC13567855

Genes

MAFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis.PMID 41842942Read ↗

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