Syndromic Inborn Errors of Immunity in TREC-Newborn Screening: 5-year Experience from the German Screening Program.

doi:10.1007/s10875-026-01995-2

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Article

Syndromic Inborn Errors of Immunity in TREC-Newborn Screening: 5-year Experience from the German Screening Program.

Journal of clinical immunology - 14 Mar 2026

Graafen Lea, Speckmann Carsten, Bakhtiar Shahrzad, Bernuth Horst V, Lehmberg Kai, Bader Peter, Baumann Ulrich, Beier Rita, Borte Stephan, Brockow Inken, Davies E Graham, Hartmann Maximilian, Holzer Ursula, Klemann Christian, Kreins Alexandra Y, Krüger Renate, Kontny Udo, Laws Hans-Jürgen, Meinhardt Andrea, Morbach Henner, Naumann-Bartsch Nora, Rothoeft Tobias, Schneider Dominik T, Willasch Andre, Worth Austen, Seidel Markus G, Albert Michael H, Ehl Stephan, Hauck Fabian, Hönig Manfred, Schulz Ansgar, Schuetz Catharina, Ghosh Sujal

Abstract excerpt

TREC-NBS identifies patients with inborn errors of immunity (IEI) and syndromic features, but uncertainty remains regarding their immunological management. To address this, syndromic patients detected by TREC-NBS in Germany between August 2019 and April 2024 were systematically analyzed, including phenotype, treatment, and outcomes. National registries were screened, and data were completed by the treating...

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PMID: 41831046
DOI: 10.1007/s10875-026-01995-2
PMCID: PMC13031199

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