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Article

Surgical Management of Stage IV Melanoma: Clinical, Molecular, and Therapeutic Considerations.

International journal of molecular sciences - 2 Mar 2026

Uche Ifeanyi K, Lyons John M

Abstract excerpt

Despite major advances in systemic therapy, surgery still plays a valuable role in the management of metastatic melanoma. This review summarizes the historical evolution of surgical management, outlines the traditional clinical risk factors, and examines biochemical, molecular, and mutational factors that impact melanoma tumor biology. Emerging tools such as predictive biomarker assays, gene expression profiling,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41828551
DOI: 10.3390/ijms27052327
PMCID: PMC12985102

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