Article
Infection of ratites with clade 2.3.4.4b HPAIV H5N1: potential implications for zoonotic risk.
Emerging microbes & infections - 1 Dec 2026
Coombes Holly A, Terrey Jacob, Schlachter Audra-Lynne, McCarter Phoebe, Regina Isabella, Hepple Richard, Mcginn Natalie, Seekings James, Cooper Jayne, Clifton Benjamin, Mollett Benjamin C, Falchieri Marco, Nunez Alejandro, Reid Scott M, James Joe, Banyard Ashley C
Abstract excerpt
We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627 K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotizing inflammation, and a strong vasculotropism.
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