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Article

Perioperative EGFR-Targeted Therapy in Resectable EGFR-Mutated NSCLC: A Narrative Review from Drug Design to Pain-Informed MRD-Guided Care.

Drug design, development and therapy - 1 Jan 2026

Xiong Lile, Yang Xiufen, Yuan Hua, Qin Lan, Lin Binghu, Chen Fengjiao, Wen Yi

Abstract excerpt

Perioperative EGFR-targeted therapy has transformed the management of resectable EGFR-mutated NSCLC. However, prolonged exposure introduces chronic toxicity and pain that may erode long-term benefit. This narrative review synthesizes evidence from pivotal perioperative EGFR-TKI trials, emerging fourth-generation EGFR-TKIs, and studies on pain, toxicity, adherence, and patient-reported outcomes, with a focus on...

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Source

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Identifiers

PMID: 41822907
DOI: 10.2147/DDDT.S587428
PMCID: PMC12978158

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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