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Environmental Mixture Toxicity of Guanitoxin and Organophosphates in Zebrafish: from Developmental and Neurobehavioral Phenotypes to Transcriptomic Responses.

Environmental science & technology - 31 Mar 2026

Souza Passos Larissa, von Wyl Melissa, Janssen Elisabeth M-L, Lopez-Rodriguez David, Pinto Ernani, Vom Berg Colette

Abstract excerpt

Guanitoxin, a neurotoxin produced by cyanobacteria and the only known naturally occurring organophosphate, poses environmental risks comparable to synthetic organophosphate insecticides. Its effects on aquatic organisms, particularly in combination with compounds sharing similar mechanisms of action, remain poorly understood. This study evaluated the developmental toxicity of guanitoxin, alone and combined with...

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PMID: 41812223
DOI: 10.1021/acs.est.5c16673
PMCID: PMC13045019

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