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Article

Myh11 haploinsufficiency recapitulates megacystis and voiding dysfunction in a mouse model of MMIHS.

Journal of pediatric urology - 1 Jun 2026

Song Jing-Yuan, Wang Wan-Lun, Liu Tong-Jia, Song Hudeer, Yang Chen-Xi, Zhang Yu-Qi, Li Peng-Fei, Xiao Rui

Abstract excerpt

BACKGROUND: Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a fatal rare disorder characterized by bladder and colonic smooth muscle dysfunction. Mutations in the MYH11 gene have been identified as one of the causative factors of MMIHS. OBJECTIVE: This study aimed to generate a Myh11 knockout mouse model, evaluate the phenotypes and function of the bladder and intestines, and investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41797110
DOI: 10.1016/j.jpurol.2026.105831

Genes

MYH11
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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