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Article

Epitope dynamics and antigenic shifts in dengue virus serotype 2 cosmopolitan genotype with structural changes in Bangladesh from 2017 to 2023.

Scientific reports - 28 Feb 2026

Alam Shaheen, Tony Selim Reza, Khair Sabik, Punno Hera Tahsin, Begum Mst Noorjahan, Rahman Mustafizur

Abstract excerpt

Dengue Virus Serotype 2 (DENV-2) is increasingly impacting public health, especially in South and Southeast Asia. Bangladesh faced its most severe dengue outbreak in 2023, reporting 318,623 cases and over 1,700 deaths, with the DENV-2 Cosmopolitan genotype responsible for 70.2% of cases. To better understand this event, we utilized in silico methods to explore mutational trends and epitope dynamics in global and...

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Identifiers

PMID: 41764225
DOI: 10.1038/s41598-026-38446-2
PMCID: PMC13057000

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