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Article

Integrating Polygenic Risk Improves Generative Forecasting of Disease Trajectories.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2026

German Chris, Shringarpure Suyash, Dibaeinia Payam, Ashenhurst James, Koelsch Bertram L, Auton Adam, Khan Aly A

Abstract excerpt

Predicting the longitudinal sequence of diseases an individual will develop over their lifetime is a central challenge in medicine. While recent AI models can process health histories, they have been limited by cohort size and the omission of genetic data. Here we introduce the Next Health Event (NHE) model, a generative transformer trained on the health trajectories of 7.1 million research participants. By using...

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PMID: 41758172
DOI: 10.1142/9789819824755_0044

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