Article
Unravelling the Evolutionary Complexity of Orf Virus: A Global and Multi-Host Perspective.
Viruses - 10 Feb 2026
Lostia Giada, Locci Chiara, Rocchigiani Angela Maria, Cacciotto Carla, Fiori Mariangela Stefania, Azzena Ilenia, Rodriguez-Valera Yoel, Pascali Alessandra Mistral De, Brandolini Martina, Pintus Davide, Ligios Ciriaco, Scagliarini Alessandra, Casu Marco, Coradduzza Elisabetta, Scarpa Fabio, Sanna Daria, Puggioni Giantonella
Abstract excerpt
Orf virus (ORFV), a member of the Parapoxvirus genus, is commonly associated with a highly infectious skin disease primarily affecting sheep and goats, with a reported zoonotic potential. Initially identified in the 18th century, ORFV has been sporadically reported in other species, including humans. The present study analyzed the genetic variability and phylodynamic patterns of ORFV using the highly variable VIR...
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