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Evaluation of Multi-Target Genotyping (ITS-hsp70-cpb) for Detecting Population Heterogeneity Within Mediterranean Leishmania infantum, with a Focus on Zymodeme MON-24.

Pathogens (Basel, Switzerland) - 29 Jan 2026

Di Muccio Trentina, Tonanzi Daniele, Van der Auwera Gert, Fiorentino Eleonora, Gradoni Luigi, Gramiccia Marina, La Rosa Giuseppe

Abstract excerpt

L. infantum and L. donovani, distinct species in the L. donovani complex, show high phenotypic and genotypic polymorphism and share molecular traits. Therefore, genotyping by a single molecular target can give uncertain results. This study focuses on genotyping a set of L. donovani complex strains, including 18 zymodemes classified according to Montpellier nomenclature (ZMONs) and different clinical forms, by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41754398
DOI: 10.3390/pathogens15020145
PMCID: PMC12942746

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